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Viruses and Glucocorticoids ‘Cooperate’ to Induce Interleukin-10 Production: Implications for Stress-Induced Immunosuppression and Exacerbations of Asthma
A study published in PLoS One may indicate a novel, unrecognized interaction between viruses and the glucocorticoid (GC)-signaling system that results in the induction of interleukin (IL)-10 production by dendritic cells (DCs).
In this report, Sinnie Ng and colleagues from the National Institutes of Child Health and Human Development, and the National Cancer Institute, National Institutes of Health (NIH), US, targeted DCs, professional antigen presenting cells that activate T cells and other immune components. Little is known about how GCs regulate the immune response, conducted by DCs, in particular during viral infection.
By using real time PCR and other techniques, the authors found that IL-10 mRNA abundance and IL-10 secretion were strongly upregulated in DCs when they were pretreated with GCs before viral infection. The authors further screened the signaling pathway responsible for this action, and found that extracellular signal-regulated kinase (ERK) inhibitors abolished the cooperation between GCs and viral infection in DCs.
This study indicates that viruses and GCs cooperatively increase IL-10 production by potentiating the transcriptional activity of GC receptors in DCs, through which viruses appear to facilitate their own propagation in infected hosts.
Read More: BrainImmune